{"id":53,"date":"2023-03-11T16:19:25","date_gmt":"2023-03-11T16:19:25","guid":{"rendered":"https:\/\/arcaid-h2020.eu\/?page_id=53"},"modified":"2023-03-17T14:07:48","modified_gmt":"2023-03-17T14:07:48","slug":"joep_longbio","status":"publish","type":"page","link":"https:\/\/arcaid-h2020.eu\/?page_id=53","title":{"rendered":"Joep_LongBio"},"content":{"rendered":"<p><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\"><strong><span style=\"color: #000000;\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-62 alignleft\" src=\"https:\/\/arcaid-h2020.eu\/wp-content\/uploads\/2023\/03\/pasfoto-joep-227x300.png\" alt=\"\" width=\"227\" height=\"300\" srcset=\"https:\/\/arcaid-h2020.eu\/wp-content\/uploads\/2023\/03\/pasfoto-joep-227x300.png 227w, https:\/\/arcaid-h2020.eu\/wp-content\/uploads\/2023\/03\/pasfoto-joep.png 355w\" sizes=\"auto, (max-width: 227px) 100vw, 227px\" \/>Joep Grootjans, MD, PhD<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\">Dr. Joep Grootjans is a physician-scientist with a special interest in inflammatory bowel diseases and cancer.<\/span><\/p>\n<p><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\">After obtaining his MD degree and Ph.D (Cum Laude) at the University of Maastricht, Joep Grootjans started his Gastroenterology &amp; Hepatology specialty training at the Amsterdam University Medical Center (AUMC, location AMC). Devoted to pursue an academic career, he interrupted his clinical training for a three year postdoctoral research in Mucosal Immunology at Harvard Medical School (Boston, USA). After his return to the Netherlands, he&nbsp;was awarded a NWO Veni grant and started his own research group while completing his clinical training. His research focuses on understanding the (immunological) mechanisms involved in immune-based diseases such as inflammatory bowel disease and cancer. As a physician scientist, his ultimate goal is to find new therapies for these diseases.<\/span><\/p>\n<p><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\"><strong>Key publications:<\/strong><\/span><\/p>\n<ul>\n<li><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\">Grootjans J, Krupka N, Hosomi S, <em>et al.&nbsp;<\/em> Epithelial endoplasmic reticulum stress orchestrates a protective microbiota-independent IgA response. <strong>Science<\/strong> 2019;363:993-998<\/span><\/li>\n<li><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\">Hosomi S, <strong>Grootjans J<\/strong>, Huang YH, Kaser A, Blumberg RS. New Insights Into the Regulation of Natural-Killer Group 2 Member D (NKG2D) and NKG2D-Ligands: Endoplasmic Reticulum Stress and CEA-Related Cell Adhesion Molecule 1. <strong>Front Immunol<\/strong>. 2018; 18(9):1324<\/span><\/li>\n<li><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\">Hosomi S*,&nbsp;Grootjans J*, Tschurtschenthaler M, <em>et al.<\/em> Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. <strong>J Exp Med.<\/strong> 2017;214(10):2985-2997 <em>*equally contributed <\/em><\/span><\/li>\n<li><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\">Grootjans J, Kaser A, Kaufman RJ, Blumberg RS. The unfolded protein response in immunity and inflammation. <strong>Nat Rev Immunol.<\/strong> 2016;16(8):469-84<\/span><\/li>\n<li><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 10pt;\">Grootjans J, Hundscheid IH, Lenaerts K, <em>et al.<\/em> Ischemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon. <strong>Gut<\/strong> 2013;62:250-258.<\/span><\/li>\n<li>Grootjans J, Hodin CM, de Haan JJ, <em style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;\">et al.<\/em><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;\"> Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia\/reperfusion. <\/span><strong style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;\">Gastroenterology <\/strong><span style=\"font-family: tahoma, arial, helvetica, sans-serif; font-size: 10pt;\">2011;140:529-539<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Joep Grootjans, MD, PhD Dr. Joep Grootjans is a physician-scientist with a special interest in inflammatory bowel diseases and cancer.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-53","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/53","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=53"}],"version-history":[{"count":2,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/53\/revisions"}],"predecessor-version":[{"id":379,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/53\/revisions\/379"}],"wp:attachment":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=53"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}