{"id":452,"date":"2023-03-17T16:16:44","date_gmt":"2023-03-17T16:16:44","guid":{"rendered":"https:\/\/arcaid-h2020.eu\/?page_id=452"},"modified":"2023-03-17T16:16:45","modified_gmt":"2023-03-17T16:16:45","slug":"full-project-description-esr-10","status":"publish","type":"page","link":"https:\/\/arcaid-h2020.eu\/?page_id=452","title":{"rendered":"Full project description ESR 10"},"content":{"rendered":"

ESR 10:<\/b> Pharmacokinetics and immunogenicity of therapeutic antibodies in inflammatory bowel disease and spondyloarthritis: A RESEARCH PROJECT ON THE EDGE BETWEEN GASTROENTERLOGY AND RHEUMATOLOGY-POSITION FILLED<\/span><\/b><\/span><\/p>\n

PhD research<\/span><\/p>\n

Hosts:<\/span><\/span><\/p>\n

Prof Dr Geert D\u2019Haens<\/span><\/strong><\/p>\n

Gastroenterologist| Professor<\/span><\/p>\n

Dr Marleen van de Sande<\/span><\/strong><\/p>\n

Rheumatologist| Assistant professor| PhD<\/span><\/p>\n

Amsterdam University Medical Centers (location AMC)<\/span><\/p>\n

Meibergdreef 9<\/span><\/p>\n

105AZ\u00a0 Amsterdam<\/span><\/p>\n

The Netherlands<\/span><\/p>\n

Duration: <\/span>48 months<\/span><\/p>\n

Background<\/span><\/span><\/p>\n

Therapeutic antibodies have become the cornerstone of effective treatment in inflammatory diseases of joints and gut. Several challenges, however, remain poorly investigated such as the prevention and treatment of immunogenicity, optimal dosing schedules and prediction of response\/failure to individual mode of actions. The current project will investigate these questions in a collaborative project in inflammatory bowel disease and spondyloarthritis patients.<\/span><\/p>\n

Approach\u00a0<\/span><\/span><\/p>\n

Key objectives are\u00a0: 1. Analyzing epigenetic profiles predicting response and failure to biological treatments. 2. Evaluate changes in immunogenicity to TNFi before and after adding methotrexate. 3. Analyze the difference in lymphoid tissue response to TNF inhibitors in patients with and without immunogenicity 4. Analyze difference in lymphoid tissue response in Crohn \u2018s patients with and without fistula\u2019s before and after treatment.<\/span><\/p>\n

Our research team<\/span><\/span><\/p>\n

It is our ambition to improve treatment outcome by personalized treatment choices based on molecular profiles as well as by optimizing dosing strategy and prevention of loss of efficacy due to immunogenicity. Within the AMC there is a close collaboration between the departments of rheumatology and gastroenterology. We are embedded in the Amsterdam Infection and Immunity research Institute as well as in the Amsterdam Gastroenterology and Metabolism research institute and Tytgat institute. We have access to high quality core research facilities of the AMC. This provides an excellent multidisciplinary research environment which form a basis for fruitful scientific collaborations between clinicians and basic scientists on our translational research projects. Prof Geert D\u2019Haens is gastroenterologist and global key opinion leader in inflammatory bowel disease with a strong translational and pharmacokinetic profile. Dr. Marleen van de Sande is rheumatologist and has a translational research line on immunopathogenesis of very early spondyloarthritis. This project will be performed in close collaboration with ARCAID PI\u2019s dr. Lisa van Baarsen (transciptomics, lymph node tissue responses), and with the radiology department.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

ESR 10: Pharmacokinetics and immunogenicity of therapeutic antibodies in inflammatory bowel disease and spondyloarthritis: A RESEARCH PROJECT ON THE EDGE<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-452","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=452"}],"version-history":[{"count":1,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/452\/revisions"}],"predecessor-version":[{"id":453,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/452\/revisions\/453"}],"wp:attachment":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}