{"id":197,"date":"2023-03-11T17:13:49","date_gmt":"2023-03-11T17:13:49","guid":{"rendered":"https:\/\/arcaid-h2020.eu\/?page_id=197"},"modified":"2023-03-17T14:00:21","modified_gmt":"2023-03-17T14:00:21","slug":"fatemeh_longbio","status":"publish","type":"page","link":"https:\/\/arcaid-h2020.eu\/?page_id=197","title":{"rendered":"Fatemeh_LongBio"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"color: #000000;\"><strong><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 14pt;\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-41 alignleft\" src=\"https:\/\/arcaid-h2020.eu\/wp-content\/uploads\/2023\/03\/Fatemeh-Khodadust-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/arcaid-h2020.eu\/wp-content\/uploads\/2023\/03\/Fatemeh-Khodadust-300x300.jpg 300w, https:\/\/arcaid-h2020.eu\/wp-content\/uploads\/2023\/03\/Fatemeh-Khodadust-150x150.jpg 150w, https:\/\/arcaid-h2020.eu\/wp-content\/uploads\/2023\/03\/Fatemeh-Khodadust.jpg 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Fatemeh Khodadustvaskasi<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #000000;\"><strong><span style=\"font-family: tahoma,arial,helvetica,sans-serif; font-size: 14pt;\">ESR18-&nbsp;<\/span><\/strong><\/span><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 14pt;\"> <strong>Molecular imaging of angiogenesis and therapeutic effects of anti-angiogenetic agents in rheumatoid arthritis<\/strong><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">Studying radiology as my bachelor\u2019s degree along with my master\u2019s degree, radiopharmaceutical sciences, provide me with a comprehensive skills and broad view in wide variety of imaging modalities.<\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">I have knowledge and experiences in radiopharmacy, radiolabeling, stability test, affinity assay,cell culture,biodistribution, human xenograft tumor mouse model, the preparation, quality control and supply of radiopharmaceuticals, biomolecules and labeled compounds, ability to work with analytical devices (TLC, HPLC) and also different imaging modalities, such as MRI, CT, X-ray tube, mammography, SPECT.<\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">The title of my master\u2019s thesis was \u201cthe influence of HYNIC chelator with Edda\/Tricine as colignds on the specific uptake and the biodistribution of SSSLTVSPWYP peptide for imaging of ovarian cancer with overexpression of HER2\u201d.<\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">This developed peptide has been proven to exhibit high contrast tumor uptake both in biodistribution data and SPECT imaging which led to further examination by my knowledgeable research group to test it for clinical application. Simultaneously, I was involved in another project with the same peptide evaluating the influence of a co-ligand for improving the targeting and imaging of HER2 overexpression tumor. I have two publication related to my master thesis:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">&#8220;An improved 99mTc-HYNIC-(Ser)3-LTVSPWY peptide with EDDA\/tricine as co-ligands for targeting and imaging of HER2 overexpression tumor. &#8221; F. Khodadust, S. Ahmadpour, N. Aligholikhamseh, S.M. Abedi, S.J. Hosseinimehr, <em>European Journal of Medicinal Chemistry<\/em>, 2018. 144: p. 767-773.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>DOI: <\/strong><span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/doi.org\/10.1016\/j.ejmech.2017.12.037\">https:\/\/doi.org\/10.1016\/j.ejmech.2017.12.037<\/a><\/span><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>Description: <\/strong>Overexpression of human epidermal receptor 2 (HER2) has given the opportunity for targeting delivery of anti-tumor drugs and radiotracers. The aim of this study was to evaluate the 99mTc-HYNIC-(EDDA\/tricine)-(Ser3)-LTVSPWY peptide for tumor targeting and imaging of tumor with overexpression of HER2.<\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">In our project, SSSLTVSPWY peptide was successfully labeled with 99mTc using HYNIC as chelator and EDDA\/tricine co-ligands to overcome the problem of time-consuming double stage direct radiolabeling procedure, with an efficient output under the mild condition and improved in vitro and in vivo findings for tumor targeting compared to previously studied radiolabeled peptide (99mTc-Cys-Ser-Ser-Ser-LTVSPWY) by our research group. The proposed labeling method having advantages of a well-defined chemistry and the ability for post conjugation labeling in which the peptide is first conjugated with a BFCA and stored for later radiolabeling process. The result of my thesis turned out to be successful and became a subject for further experiment on clinical stage. For my project, radiolabeling, the in vitro stability, cellular affinity, animal biodistribution in<\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">tumor bearing mice and imaging have been performed.<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">&#8221; 99mTc-HYNIC-(Ser)3-LTVPWY peptide bearing tricine as co-ligand for targeting and imaging of HER2 overexpression tumor.&#8221; N. Aligholikhamseh, S. Ahmadpour, F. Khodadust, S.M. Abedi, S.J Hosseinimehr, <em>Radiochimica Acta<\/em>, 2018. 106(7), 601-609.<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>DOI: <\/strong><a style=\"color: #000000;\" href=\"https:\/\/doi.org\/10.1515\/ract-2017-2868\"><span style=\"color: #0000ff;\">https:\/\/doi.org\/10.1515\/ract-2017-2868<\/span><\/a><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>Description: <\/strong>In other project with the same peptide (99mTc-HYNIC-(tricine)-(Ser)3-LTVSPWY peptide) labeling procedure have been evaluated with different coligand (tricine). It was investigated for HER2 binding affinity, targeting and imaging of HER2+ ovarian cancer. This radiolabeled peptide exhibited <em>in vitro <\/em>affinity and <em>in vivo <\/em>tumor targeting. The HYNIC-(Ser)3-LTVSPWY peptide was successfully labeled with 99mTc using tricine as a co-ligand at room temperature in order to make the radiolabeling procedure easier without the need for heating. Using tricine as coligand and tri-serine as spacer give a hydrophilic nature to this radiolabeled peptide which lead to fast clearance from kidneys and blood leading to rapid washout from non-targeted tissues in xenografted nude mice.The tumor\/muscle ratio of 99mTc-HYNIC-peptide was lower than cysteine based peptide and tumor uptake was visualized at 4 h after injection of 99mTc-HYNIC-tricine-(Ser)3 LTVSPWY in SPECT imaging. For labeling of this peptide with 99mTc , practicing other co-ligands and chelators to achieve better tumor targeting and imaging is recommended.<\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">My academic background:<\/span><\/p>\n<table>\n<tbody>\n<tr>\n<td><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">September2015- May 2018<\/span><\/td>\n<td><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>Master&#8217;s Degree in Radiopharmaceutical Sciences <\/strong><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><em>Mazandaran University of Medical Sciences <\/em><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><em>Sari, Mazandaran Province, Iran<\/em><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>&nbsp;<\/strong><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>Thesis title: <\/strong>The Influence of HYNIC Chelator with EDDA\/Tricine as Colignds on the Specific Uptake and the Biodistribution of SSSLTVSPWYP Peptide for Imaging of Ovarian Cancer with Overexpression of HER2<\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>Thesis Supervisor: <\/strong>Prof. Seyed Jalal Hosseinimehr<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">February 2013- February 2015<\/span><\/td>\n<td><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>Bachelor&#8217;s Degree in Radiology <\/strong><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><em>Mazandaran University of Medical Sciences <\/em><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><em>Sari, Mazandaran Province, Iran <\/em><\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\">September2007-July 2009<\/span><\/td>\n<td><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><strong>Associate&#8217;s Degree in Radiology <\/strong><\/span><\/p>\n<p><span style=\"color: #000000; font-family: tahoma,arial,helvetica,sans-serif; font-size: 12pt;\"><em>Mazandaran University of Medical Sciences <\/em><\/span><\/p>\n<p><span style=\"color: #000000; font-size: 12pt;\"><em><span style=\"font-family: tahoma,arial,helvetica,sans-serif;\">Sari, Mazandaran Province, Iran<\/span> <\/em><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: left;\">\n","protected":false},"excerpt":{"rendered":"<p>Fatemeh Khodadustvaskasi ESR18-&nbsp; Molecular imaging of angiogenesis and therapeutic effects of anti-angiogenetic agents in rheumatoid arthritis Studying radiology as my<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-197","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=197"}],"version-history":[{"count":2,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/197\/revisions"}],"predecessor-version":[{"id":353,"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=\/wp\/v2\/pages\/197\/revisions\/353"}],"wp:attachment":[{"href":"https:\/\/arcaid-h2020.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}