ESR 1: Initiate a pilot prevention trial in individuals at high risk for developing rheumatoid arthritis

Host:

Prof. Dr Ronald van Vollenhoven

Amsterdam Rheumatology and immunology Center (ARC)

Department of Rheumatology & Clinical Immunology

Amsterdam UMC, location AMC

Duration: 48 months

The PhD candidate will plan and initiate a clinical trial in individuals who are at high risk of acquiring rheumatoid arthritis (RA); this work will include developing the protocol, obtaining the necessary approvals, and establishing the needed collaborations. At-risk individuals will be identified using a combination of clinical and laboratory variables, and randomly assigned to treatment with an immunomodulator or placebo. [Full project description].

 

ESR 2: Clinical studies of treating-to-target in patients with systemic lupus erythematosus

Host:

Prof. Dr Ronald van Vollenhoven

Amsterdam Rheumatology and immunology Center (ARC)

Department of Rheumatology & Clinical Immunology

Amsterdam UMC, location AMC

Duration: 48 months

The PhD candidate will plan and initiate a pilot clinical trial for patients with systemic lupus erythematosus (SLE) to test the proposed strategy of “treating-to-target” (T2T) with remission as the target. This work will include developing the protocol, obtaining the necessary approvals, and establishing the needed collaborations. Patients will be randomly assigned to T2T vs. regular care treatment. [Full project description].

 

ESR 3: Gene expression in the HLA complex in autoimmune disease (Position filled!!)

Host:

Prof. Dr. Niek de Vries

Amsterdam Rheumatology and immunology Center (ARC)

Rheumatology & Clinical Immunology & Experimental Immunology

Amsterdam UMC, location AMC/VUMC

Duration: 48 months

 

ESR 4: Clonal isotyping of the B cell response in autoimmunity (Position filled!!)

Host:

Prof. Dr. Niek de Vries

Amsterdam Rheumatology and immunology Center (ARC)

Rheumatology & Clinical Immunology & Experimental Immunology

Amsterdam UMC, location AMC/VUMC

Duration: 48 months

 

ESR 5: Study the molecular and cellular features of human lymph node T cells during the earliest phases of systemic autoimmunity (Position filled!!)

Host:

Dr Lisa van Baarsen

Amsterdam Rheumatology and immunology Center (ARC)

Department of Experimental Immunology

Amsterdam UMC, location AMC

Duration: 48 months

 

ESR 6: Mesenchymal stromal cells as key orchestrators in RA (Position filled!!)

Host:

Dr Lisa van Baarsen

Amsterdam Rheumatology and immunology Center (ARC)

Department of Experimental Immunology

Amsterdam UMC, location AMC

Duration: 48 months

The PhD candidate will perform in depth molecular and cellular analyses of stromal cells derived from bone marrow, lymph node and synovial tissue biopsies obtained during the earliest (preclinical) phases of RA. The ultimate goal is to identify targets that can be manipulated to regulate stromal cell function, which may lay the foundation for preventive intervention and immunomodulation. [Full project description].

 

ESR 7: The B cell lineage in ANCA-associated vasculitis: functional characterisation and identification of novel targets

Host:

Dr. S.W. Tas

Department of Rheumatology & Clinical Immunology

Laboratory for Experimental Immunology

Amsterdam UMC, location AMC/VUMC

Duration: 48 months

The PhD candidate will investigate the B cell lineage in ANCA-associated vasculitis aimed at functional characterisation and identification of novel targets. This research project will be the first to investigate B lineage cells in AAV in 3 different compartments of the immune system: peripheral blood, lymph nodes and bone marrow. We will use a novel cutting edge technology such as multi-parameter CyTOF PhosphoFlow, RNA- and ChIP-sequencing. Ultimately, we will also validate various therapeutic targets in an animal model of AAV. These types of experiments have not been performed previously and the impact of the findings is likely to reach beyond AAV, as it may simultaneously advance our understanding of fundamental B cell biology in general and of principles that are shared between AAV and other systemic autoimmune diseases such as primary Sjögren’s Syndrome, SLE and RA. [Full project description]

 

ESR 8: State-of-the-art in vivo PET-CT imaging of immune cell subsets in chronic inflammatory diseases and cancer

Host:

Dr. S.W. Tas

Department of Rheumatology & Clinical Immunology

Laboratory for Experimental Immunology

Amsterdam UMC, location AMC/VUMC

Duration: 48 months

The PhD candidate will develop PET-CT imaging of immune cell subsets and soluble mediators in chronic inflammatory diseases and cancer. This research project will be truly translational: we will start with in vitro studies to develop novel tracers, followed by in vivo studies in preclinical models and ultimately proof-of-concept studies in humans, including correlation of imaging results with ex vivo tissue analysis. The overarching goal of this project is to develop a novel strategy to visualize to what extent these diseases are driven by specific immune cell subsets or certain soluble mediators in the individual patient, which may ultimately predict to what therapy the individual patient may respond best (i.e. checkpoint inhibitors, cytokine inhibitors or depleting antibodies). This concept will also be tested in disease models. These unique experiments have not been performed previously and the impact of the findings is likely to be big, as it may advance our understanding of pathological processes that play an important role in these diseases and ultimately guide treatment decisions. [Full project description]

 

ESR 9: Characterize the molecular pathways activated during the pre-clinical phase of spondyloarthritis (Position filled!!)

Host:

Dr Marleen van de Sande

Amsterdam Rheumatology and immunology Center (ARC)

Department of Rheumatology & Clinical Immunology

Amsterdam UMC, location AMC

Duration: 48 months

 

ESR 10: Pharmacokinetics and immunogenicity of therapeutic antibodies in inflammatory bowel disease and spondyloarthritis: A RESEARCH PROJECT ON THE EDGE BETWEEN GASTROENTERLOGY AND RHEUMATOLOGY (Position filled!!)

Hosts:

Prof Dr Geert D’Haens

Gastroenterologist| Professor

Dr Marleen van de Sande

Amsterdam Rheumatology and immunology Center (ARC)

Department of Rheumatology & Clinical Immunology

Amsterdam UMC, location AMC

Duration: 48 months

 

ESR 11: Understanding auto-immune disorders through computational modelling.

Hosts:

Prof. dr. A.H.C. van Kampen (Antoine)

Bioinformatics Laboratory

Clinical Epidemiology, Biostatistics, and Bioinformatics

Amsterdam UMC, location AMC

https://bioinformatics.amc.nl/

 

Dr Lisa van Baarsen

Amsterdam Rheumatology and immunology Center (ARC)

Department of Experimental Immunology

Amsterdam UMC, location AMC

Duration: 48 months

The molecular and cellular mechanisms underlying autoimmune disorders such as rheumatoid arthritis are not well understood. In this project we aim to combine (single cell) omics data and (multi-scale) computational modelling to gain further insight in these disorders [Full project description].

 

ESR 12: Bioinformatics analysis of T-cell and B-cell repertoires (Position filled!!)

Host:

Prof. dr. A.H.C. van Kampen (Antoine)

Bioinformatics Laboratory

Clinical Epidemiology, Biostatistics, and Bioinformatics

Amsterdam UMC, location AMC

https://bioinformatics.amc.nl/ 

Duration: 48 months

 

ESR 13: Understanding the etiology of IBD associated extraintestinal manifestations and cancer- (Position filled!!)

Host:

Prof Dr Geert D’Haens

Gastroenterologist| Professor

Dr Joep Grootjans

Fellow Gastroenterology & Hepatology | PhD

Amsterdam UMC, location AMC

Duration: 48 months

 

ESR 14: Activated PI3 kinase delta in systemic lupus erythematosus (SLE)- (Position filled!!)

Hosts:

Prof. dr. Sergey Nejentsev

Department of Molecular Cell Biology and Immunology

Amsterdam UMC, location VUMC

Prof. dr. Alexandre Voskuyl

Department of Rheumatology

Amsterdam UMC, location VUMC

Duration: 48 months

 

ESR 15: Uncovering how HIV hides in immune cells: metabolic reprogramming of CD4 T cells during infection (Position filled!!)

Host:

Dr. Jeroen den Dunnen

Amsterdam Rheumatology and immunology Center (ARC)

Rheumatology & Clinical Immunology

Experimental Immunology

Amsterdam UMC, location AMC

Duration: 48 months

 

ESR 16: Metabolic reprogramming of human myeloid immune cells during chronic inflammation (Position filled!!)

Host:

Dr. Jeroen den Dunnen

Amsterdam Rheumatology and immunology Center (ARC)

Rheumatology & Clinical Immunology

Experimental Immunology

Amsterdam UMC, location AMC

Duration: 48 months

 

ESR 17: Immune monitoring of macrophages in the development and progression of rheumatoid arthritis and immune checkpoint inhibitor-induced rheumatic manifestations (Position filled!!)

Host:

Dr Conny J. van de Laken

Department of Rheumatology

Amsterdam UMC, location VUMC

Duration: 48 months

 

ESR 18: Molecular imaging of angiogenesis and therapeutic effects of anti-angiogenetic agents in rheumatoid arthritis (Position filled!!)

Host:

Dr Conny J. van de Laken

Department of Rheumatology

Amsterdam UMC, location VUMC

Duration: 48 months

 

ESR 19: Development of immune competent gut on chip model (Position filled!!)

Hosts:

Prof. Dr. Sue Gibbs/ Prof. Dr. Reina Mebius

Department of Molecular Cell Biology and Immunology

Amsterdam UMC, location VUMC

Duration: 48 months

 

ESR 20: Development of immune competent lymph node on chip model including lymph node stromal cells, lymphocytes, and dendritic cells. (Position filled!!)

Hosts:

Prof. Dr. Sue Gibbs/ Prof. Dr. Reina Mebius

Department of Molecular Cell Biology and Immunology

Amsterdam UMC, location VUMC

Duration: 48 months