Sergey Nejentsev

Prof. dr. Sergey Nejentsev
Professor of Translational Immunology

Department of Molecular Cell Biology and Immunology (MCBI),
Amsterdam University Medical Centers , Location VUmc,
Amsterdam, Netherlands

Department of Medicine,
University of Cambridge,
Cambridge, UK


Prof. dr. Sergey Nejentsev is a researcher at the Amsterdam UMC and the University of Cambridge. He graduated as a paediatrician and obtained PhD in medical genetics. From 2001 he studied genetics of autoimmune diseases at the University of Cambridge (e.g. Nejentsev et al, Lancet 2003; Nejentsev et al, Nature 2007; Nejentsev et al, Science 2009). In 2008 he established his research group at the University of Cambridge that investigated genetic and functional mechanisms of susceptibility to tuberculosis (Curtis et al, Nat Genet 2015) as well as immunodeficiency disorders. Research led by Prof. Nejentsev discovered several novel primary immunodeficiencies, including JAK1 deficiency (Eletto et al, Nat Commun 2016), RIPK1 deficiency (Cuchet-Lourenco et al, Science 2018) and a widely known disease, the Activated PI3 kinase Delta Syndrome (APDS; Angulo et al, Science 2013). His research was funded by prestigious awards, including Royal Society University Research Fellowship, Wellcome Trust Senior Fellowship, ERC Starting grant and the recently awarded ERC Advanced grant.

Key publications:
1 Nejentsev S, Guja C, McCormack R, Cooper J, Howson J, Nutland S, Rance H, Walker N, Undlien D, Ronningen K, Tuomilehto-Wolf E, Tuomilehto J, Ionescu-Tirgoviste C, Gale E, Bingley PJ, Gillespie KM, Savage D, Carson DJ, Patterson CC, Maxwell AP, Todd JA:
Association of intercellular adhesion molecule-1 gene with type 1 diabetes.
Lancet 362:1723-4, 2003

2 Nejentsev S, Howson JMM, Walker NM, Szeszko JS, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LMM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA and The Wellcome Trust Case Control Consortium:
Localisation of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450: 887-92, 2007

3 Nejentsev S, Walker N, Riches D, Egholm M, Todd JA:
Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes. Science 324: 387-9, 2009

4 Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers E, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S:
Phosphoinositide 3-Kinase delta Gene Mutation Predisposes to Respiratory Infection and Airway Damage. Science 342:866-71, 2013

5 Curtis J, Luo Y, Zenner HL, Cuchet-Lourenco D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nurnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S:
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet 47:523-527, 2015

6 Eletto D, Burns SO, Angulo I, Plagnol V, Gilmour KG, Henriquez F, Curtis J, Gaspar M, Nowak K, Daza-Cajigal V, Kumararatne D, Doffinger R, Thrasher AJ, Nejentsev S:
Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection.
Nat Commun 7:13992, 2016

7 Cuchet-Lourenco D, Eletto D, Wu C, Plagnol V, Papapietro O, Curtis J, Ceron-Gutierrez L, Bacon CM, Hackett S, Alsaleem B, Maes M, Gaspar M, Alisaac A, Goss E, Siegmund D, Wajant H, Kumararatne D, AlZahrani MS, Arkwright PD, Abinun M, Doffinger R and Nejentsev S:
Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis and intestinal inflammation. Science 361:810-3, 2018